AOD-9604

AOD-9604 is supplied as a laboratory research reference material intended for in-vitro and laboratory research use only. Structurally, it is a synthetic 16-residue modified analog derived from the C-terminal region of human growth hormone (residues 176-191), presenting the primary sequence YLRIVQCRSVEGSCGF (Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe) with an intramolecular disulfide bridge locking Cys-7 to Cys-14 into a constrained loop. An N-terminal tyrosine addition distinguishes AOD-9604 from the unmodified parent fragment and provides a UV-active handle useful for 280 nm detection during chromatographic characterization.

The peptide is defined by the molecular formula C78H123N23O23S2, an average molecular weight of 1815.1 g/mol, and a monoisotopic mass of 1813.8604 Da, corresponding to CAS 221231-10-3 and PubChem CID 71300630. Additional cheminformatics identifiers include the InChIKey GVIYUKXRXPXMQM-BPXGDYAESA-N and a canonical SMILES string capturing the disulfide-cyclized backbone, supporting unambiguous cross-referencing across analytical databases and laboratory information systems.

Supplied as a synthetic, lyophilized white to off-white powder under catalog identifier AOD-9604, this reference material carries a specified purity of not less than 98% as determined by reverse-phase HPLC, with identity typically corroborated by ESI or MALDI mass spectrometry against the expected monoisotopic mass. The composition includes multiple polar and ionizable residues (two arginines, one glutamic acid, two serines, one glutamine, one tyrosine) alongside hydrophobic isoleucine, leucine, valine, and phenylalanine side chains, giving AOD-9604 a mixed amphipathic character relevant to solvent selection, reconstitution studies, and stability profiling in analytical workflows.

Published scientific literature has examined AOD-9604 in preclinical research; PEPTIDE.Power makes no therapeutic, diagnostic, or efficacy claims regarding this material and provides no administration or dosing guidance. As a cyclic disulfide-containing peptide, AOD-9604 warrants standard handling considerations for cysteine-bearing sequences, including protection from oxidative and reductive conditions during reference-standard preparation, and storage of the lyophilizate under cool, dry, light-protected conditions to preserve analytical integrity.

This material is not a drug, supplement, cosmetic, or food, and is not for human or veterinary use, injection, or ingestion. Identity and purity for each production lot of AOD-9604 are documented on a lot-specific Certificate of Analysis, available on request, which reports HPLC purity, mass-spectrometric identity confirmation, appearance, and applicable residual-solvent or counterion data to support reproducibility in downstream analytical and comparative laboratory studies.