Epithalon

Epithalon is supplied as a laboratory research reference material for in-vitro and laboratory research use only. It is a fully synthetic linear tetrapeptide composed of four residues (Ala-Glu-Asp-Gly, one-letter AEDG), presenting a free N-terminal alanine amine and a C-terminal glycine carboxylate, with two additional pendant carboxylic acid groups contributed by the internal glutamic and aspartic acid side chains. This acidic side-chain profile gives Epithalon a low isoelectric point and strong aqueous solubility in neutral to mildly basic buffers, a property useful when preparing stock solutions for analytical characterization work.

Identity is defined by molecular formula C14H22N4O9, monoisotopic mass 390.1387 Da, average molecular weight 390.35 g/mol, and CAS 307297-39-8, cross-referenced to PubChem CID 219042 and InChIKey HGHOBRRUMWJWCU-FXQIFTODSA-N. The canonical SMILES CC(C(=O)NC(CCC(=O)O)C(=O)NC(CC(=O)O)C(=O)NCC(=O)O)N encodes the L-configured Ala-Glu-Asp-Gly backbone with three amide bonds linking the four residues. The material is produced by chemical synthesis and supplied as a white to off-white lyophilized powder at not less than 98% purity by HPLC, with lot-specific identity, purity, and residual profile documented on the Certificate of Analysis available on request.

Published scientific literature has examined Epithalon in preclinical research contexts, and it is frequently referenced by investigators evaluating short acidic peptides, HPLC method development, mass spectrometric identification workflows (expected [M+H]+ near 391.15), and comparative stability studies of small oligopeptides bearing multiple carboxylate functionalities. Because of the two free carboxylic acids and the free primary amine, Epithalon is a useful reference standard for reversed-phase separations, ion-pair chromatography, and calibration of low-molecular-weight peptide assays.

For storage and handling in the laboratory, the lyophilized powder is typically kept sealed, protected from moisture and light, and reconstituted only in analytically appropriate solvents at the time of use to preserve chromatographic integrity. PEPTIDE.Power makes no therapeutic, diagnostic, or efficacy claims regarding Epithalon and provides no administration or dosing guidance. This material is not a drug, supplement, cosmetic, or food, and is not for human or veterinary use, injection, or ingestion; it is intended solely as a laboratory reference substance for qualified research personnel working in a controlled research setting.