Semax

Semax is supplied as a laboratory research reference material intended strictly for in-vitro and laboratory research use only. This synthetic heptapeptide is a structural analog derived from a fragment of adrenocorticotropic hormone (ACTH 4-10), extended at the C-terminus with a Pro-Gly-Pro tripeptide motif that alters its physicochemical profile relative to the parent ACTH sequence. The linear seven-residue sequence is MEHFPGP (Met-Glu-His-Phe-Pro-Gly-Pro), incorporating a sulfur-containing methionine at the N-terminus, an acidic glutamate, an imidazole-bearing histidine, an aromatic phenylalanine, and two proline residues flanking a central glycine.

The Semax reference material is characterized by the molecular formula C37H51N9O10S, an average molecular weight of 813.9 g/mol, and a monoisotopic mass of 813.3480 Da, corresponding to CAS 80714-61-0 and PubChem CID 9811102. Stereochemistry and connectivity are captured by InChIKey AFEHBIGDWIGTEH-AQRCPPRCSA-N and the canonical SMILES string CSCCC(C(=O)NC(CCC(=O)O)C(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)N3CCCC3C(=O)NCC(=O)N4CCCC4C(=O)O)N, providing unambiguous identifiers for cross-referencing in analytical databases and cheminformatics workflows.

Each lot of Semax is produced by chemical synthesis and presents as a white to off-white lyophilized powder. Purity is not less than 98% as determined by HPLC, with identity, purity, mass confirmation and residual profile documented on the lot-specific Certificate of Analysis available on request. The methionine thioether and histidine imidazole are known handles that formulators typically consider when planning solvent compatibility, buffer selection, and long-term storage studies of research peptides of this class.

Published scientific literature has examined Semax in preclinical and in-vitro research contexts, and the identifiers above allow investigators to align in-house analytical data with peer-reviewed reports. PEPTIDE.Power makes no therapeutic, diagnostic, or efficacy claims regarding this material and provides no administration or dosing guidance. This material is not a drug, supplement, cosmetic, or food, and is not for human or veterinary use, injection, or ingestion.