CJC 1295 (Without DAC)

CJC-1295 (No DAC) is supplied by PEPTIDE.Power as a laboratory research reference material intended solely for in-vitro and laboratory research use. It corresponds to a synthetic 29-residue analog of the N-terminal fragment of growth hormone-releasing hormone, GHRH(1-29), incorporating four defined amino-acid substitutions relative to the native human sequence (positions 2, 8, 15, and 27) that are commonly used in peptide chemistry to reduce enzymatic cleavage susceptibility and improve chromatographic handling of the reference material.

The material is characterized by molecular formula C152H252N44O42, an average molecular weight of approximately 3367.9 g/mol, and a monoisotopic mass of 3365.8936 Da, with CAS Number 863288-34-0 and PubChem CID 56841945. Its primary structure is defined by the one-letter sequence YADAIFTQSYRKVLAQLSARKLLQDIMSR, corresponding to Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg. The InChIKey XOZMWINMZMMOBR-HRDSVTNWSA-N and a canonical SMILES string are recorded on file to support unambiguous structural identification, computational cross-referencing, and database lookup by analytical laboratories.

Unlike DAC-modified GHRH analog variants, CJC-1295 (No DAC) carries no drug affinity complex conjugation moiety on the C-terminal lysine, so the free peptide backbone described here has the mass and formula listed above rather than those of a maleimidopropionyl-bearing conjugate. This distinction is relevant for mass-spectrometric identity confirmation, HPLC retention behavior, and comparative reference work against related GHRH(1-29)-family research peptides.

Physically, CJC-1295 (No DAC) is presented as a white to off-white lyophilized powder produced by solid-phase peptide synthesis from synthetic amino-acid precursors, with a stated purity of not less than 98% by HPLC. Each lot is accompanied by a lot-specific Certificate of Analysis documenting identity (typically by mass spectrometry against the theoretical monoisotopic mass), chromatographic purity, and appearance; the CoA is available on request and remains the authoritative source of lot-level analytical data. Researchers should note the presence of a methionine residue (position 27), which is a consideration for oxidation monitoring during analytical method development, and two arginine and two lysine residues that inform ion-exchange behavior and predicted net charge.

Published scientific literature has examined CJC-1295 (No DAC) in preclinical research contexts, and it is offered here strictly as a characterized reference substance to support such investigations. PEPTIDE.Power makes no therapeutic, diagnostic, or efficacy claims regarding this material and provides no administration, dosing, or handling-for-use guidance. This material is not a drug, dietary supplement, cosmetic, or food; it is not for human or veterinary use, and it is not intended for injection, ingestion, topical application, or any other in-vivo administration.