Humanin

Humanin is offered as a laboratory research reference material intended for in-vitro and laboratory research use only. This synthetic 24-residue peptide corresponds to the sequence Met-Ala-Pro-Arg-Gly-Phe-Ser-Cys-Leu-Leu-Leu-Leu-Thr-Ser-Glu-Ile-Asp-Leu-Pro-Val-Lys-Arg-Arg-Ala (one-letter: MAPRGFSCLLLLTSEIDLPVKRRA), catalogued under CAS 330936-69-1 and SKU HUMANIN for straightforward inventory tracking in analytical workflows.

The molecular formula C112H184N28O30S2 corresponds to a monoisotopic-compatible average molecular weight of 2438.0 g/mol, reflecting a hydrophobic core dominated by a Leu-Leu-Leu-Leu tetrad and flanking aliphatic residues (Ile, Val, Ala), a single sulfur-bearing cysteine at position 8, an N-terminal methionine, and a basic C-terminal cluster (Lys-Arg-Arg) that contributes to the peptide’s net charge profile at physiological pH ranges relevant to buffer selection. The lone Cys residue is a point of analytical attention for investigators developing HPLC or LC-MS methods, since free thiol chemistry can influence chromatographic retention, disulfide-mediated dimerization, and oxidation state during handling.

Humanin is produced by solid-phase peptide synthesis and supplied as a white to off-white lyophilized powder with purity not less than 98% by HPLC, as documented on the lot-specific Certificate of Analysis. The CoA typically reports reverse-phase HPLC purity, mass confirmation consistent with 2438.0 g/mol, sequence verification, and appearance, giving analytical chemists and formulation scientists a defensible identity and purity record for method development, reference standard preparation, assay calibration, and comparative characterization studies.

Published scientific literature has examined Humanin in preclinical research contexts, and the peptide is frequently cited as a mitochondrial-derived 24-mer of interest in biochemistry and molecular biology reference collections. PEPTIDE.Power makes no therapeutic, diagnostic, or efficacy claims regarding this material and provides no administration or dosing guidance; its listing here is strictly as a characterized chemical reference item.

This material is not a drug, supplement, cosmetic, or food, and is not for human or veterinary use, injection, or ingestion. It is sold exclusively for in-vitro laboratory research, analytical reference, and method-development purposes by qualified professionals. Identity and purity are documented on the lot-specific Certificate of Analysis, available on request.