5-Amino-1MQ

5-Amino-1MQ is supplied as a laboratory research reference material intended strictly for in-vitro and other laboratory research use. The compound is a small-molecule quaternary quinolinium salt referenced in the published literature as a selective inhibitor of nicotinamide N-methyltransferase (NNMT), studied in preclinical enzymology and cell-based assay systems.

Structurally, 5-Amino-1MQ (5-amino-1-methylquinolinium) consists of a quinoline scaffold bearing a primary amine at the 5-position and a permanent positive charge on the ring nitrogen introduced by N1-methylation. The cationic core corresponds to the free-base formula C10H11N2+ with a formula weight of 215.26 g/mol and CAS 1034043-18-3. Commonly encountered salt forms include the iodide (C10H11IN2) and chloride (C10H11ClN2); PubChem indexes the free base under CID 950107 and the iodide salt under CID 66522933. The canonical SMILES is C[N+]1=CC=CC2=C(C=CC=C21)N, the InChIKey is ZMJBCEIHNOWCMC-UHFFFAOYSA-O, and the monoisotopic mass of the cation is 159.0922 Da, providing convenient reference points for LC-MS confirmation and library matching.

Physical form is a white to off-white lyophilized powder produced by chemical synthesis, with purity of not less than 98% as determined by HPLC. The permanent quinolinium charge typically confers high aqueous solubility of the salt forms, making 5-Amino-1MQ convenient to reconstitute for analytical characterization workflows, orthogonal identity confirmation (HPLC-UV, LC-MS, NMR), and use as a chromatographic or spectroscopic reference standard alongside NNMT substrate/product analytes such as nicotinamide and 1-methylnicotinamide.

Published scientific literature has examined 5-Amino-1MQ in preclinical research contexts; PEPTIDE.Power makes no therapeutic, diagnostic, or efficacy claims regarding this material and provides no administration or dosing guidance. This material is not a drug, supplement, cosmetic, or food, and is not for human or veterinary use, injection, or ingestion. Lot-specific identity, purity, and counterion documentation are captured on the Certificate of Analysis, available on request.